NEW YORK (Reuters Health) – Increases in the genetic burden of LRRK2 risk variants are associated with an earlier age at onset of Parkinson’s disease (PD) in Asians, a new study suggests.
The S1647T, R1628P, and G2385R variants of LRRK2 are established risk factors for PD in Asian populations. However, it’s not known whether the presence of multiple LRRK2 risk variants influences the age of PD onset.
To investigate, Dr. Eng-King Tan from National Neuroscience Institute in Singapore and colleagues assessed associations of these LRRK2 risk variants with age at onset (AAO) in 1,284 Asian patients with PD.
For the entire cohort, the average AAO of PD was 62.3 years, with women developing PD later than men (63.3 vs. 61.6 years). A total of 495 patients had no S1647T, R1628P, or G2385R variant, while 789 carried at least one of those risk variants.
The average AAO of individuals with no risk variants was 62.5 years; it was 62.3 years in those with one risk variant, 61.3 years in those with two variants and 52.6 years in those with three risk variants.
Of the 10 people carrying all three variants, four (40%) developed PD before age 50, while only 51 of the 495 noncarriers (10.3%) reported their first PD-related complaint before age 50.
The researchers say results of an independent Asian cohort of 465 patients from Malaysia support their findings. They identified four patients with all three risk alleles in the Malaysian cohort. The AAOs for these four individuals were 45, 49, 57, and 59 years, respectively, with a mean AAO of 52.5 years, which was lower than the mean of 60.1 for noncarriers.
“Our data show that the presence of multiple risk variants in a patient with PD may significantly lower the AAO of PD,” they conclude.
SOURCE: http://bit.ly/2yLWrDV
JAMA Neurol 2017.
Tidak ada komentar:
Posting Komentar